Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 1.00 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL715802 | 1.00 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL2235356 | 1.00 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL276988 | 1.00 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL11060179 | 1.00 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL25212993 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL6690080 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL10692975 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL21694724 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL20917176 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL10692967 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 643280 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344869-A | Method for synthesizing fluorescent powder by hydrothermal method | 南通大学 | 2024-07-16 | — | — | CN | claimed |
| CN-118348158-A | Method for detecting content of magnaline, icariine and epimedin C in traditional Chinese medicine compound granule containing epimedium herb by utilizing near infrared spectrum and application thereof | 贵州富华药业有限责任公司 | 2024-07-16 | — | — | CN | claimed |
| CN-117761969-B | Stripping liquid and preparation method and application thereof | 四川熔增环保科技有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-118344250-A | Resource recycling method for sodium citrate and sodium sulfate mixed solution | 世韩(天津)节能环保科技有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-118347993-A | Ag@EuW based10Preparation of carbohydrate antigen 19-9 (CA 19-9) of PEI | 济南大学 | 2024-07-16 | — | — | CN | claimed |
| CN-118344934-A | Bio-based fluorine-free water repellent agent for synthetic leather and preparation method thereof | 德雄实业(浙江)有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-118348092-A | RGO-CeO-based2Sandwich type aptamer sensor for detecting GPC3 by Au NPs construction | 桂林电子科技大学 | 2024-07-16 | — | — | CN | claimed |
| CN-118344619-A | Hydrogel for detecting alkaline phosphatase based on double modes, preparation method and application thereof | 上海工程技术大学 | 2024-07-16 | — | — | CN | claimed |
| CN-118344936-A | Contact lens care solution capable of relieving eye dryness and preparation method thereof | 深圳市眼学科技有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-116812982-B | Co-Fe2O3Preparation method of/Au-rGO multi-heterojunction nano-material and gas sensor | 中国科学院空天信息创新研究院 | 2024-07-12 | — | — | CN | claimed |
| US-3947570-A | MOUTHWASH, LEMON OIL | COLGATE-PALMOLIVE COMPANY (US) | 1976-03-30 | — | — | US | claimed |
| US-3945951-A | ANTIOXIDANTS, SULFIDES, OXY, CARBO | KAO SOAP CO., LTD. (JA) | 1976-03-23 | — | — | US | claimed |
| US-3941723-A | Crystallized alkali metal silicate with sequestering agents | PHILADELPHIA QUARTZ COMPANY (US) | 1976-03-02 | — | — | US | claimed |
| US-3937282-A | Method for cementing wells in low temperature formations | HALLIBURTON COMPANY (US) | 1976-02-10 | — | — | US | claimed |
| US-3936434-A | Cytobiotic globulins for kidney treatment | OMNIUM FINANCIER AQUITAINE POUR L'HYGIENE ET LA SANTE (SANOFI) (FR) | 1976-02-03 | — | — | US | claimed |
| US-3935323-A | CHEESE WHEY | STAUFFER CHEMICAL COMPANY (US) | 1976-01-27 | — | — | US | claimed |
| US-3932618-A | REACTION PRODUCT OF BLOOD AND A PROTEASE | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JA) | 1976-01-13 | — | — | US | claimed |
| US-3932680-A | STABILIZERS | ZENTRALSCHWEIZERISCHER MILCHVERBAND (CH) | 1976-01-13 | — | — | US | claimed |
| US-3932655-A | CHELATING AGENTS, N-ALKYL BENZALKONIUM CHLORIDES | INTERNATIONAL PHARMAKON LABORATORIES, INC. (US) | 1976-01-13 | — | — | US | claimed |
| US-3930896-A | NICKEL-COBALT ALLOY | TATSUTA DENSEN KABUSHIKI KAISHA (JA) | 1976-01-06 | — | — | US | claimed |