Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL260176 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL372188 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL372670 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL6692872 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL3775695 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL6692875 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL25212993 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL372534 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL372244 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL5163322 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230181555-A1 | STABLE AND PRESERVED PHARMACEUTICAL COMPOSITIONS OF BILASTINE | FAES FARMA, S.A. (ES) | 2023-06-15 | — | — | US | disclosed |
| US-11642309-B2 | Aqueous compositions comprising bilastine and mometasone | FAES FARMA, S.A. (ES) | 2023-05-09 | — | — | US | disclosed |
| US-20210186869-A1 | AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE | FAES FARMA, S.A. (ES) | 2021-06-24 | — | — | US | disclosed |
| EP-3681475-B1 | AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE | FAES FARMA SA (ES) | 2020-12-09 | — | — | EP | disclosed |
| EP-3725298-A1 | STABLE AND PRESERVED PHARMACEUTICAL COMPOSITIONS OF BILASTINE | FAES FARMA, S.A. (ES) | 2020-10-21 | — | — | EP | disclosed |
| EP-3681475-A1 | AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE | FAES FARMA, S.A. (ES) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019076798-A1 | AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE | FAES FARMA, S.A. (ES) | 2019-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210186869-A1 | AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE | HRH4, HRH2, HRH1 | CA4 955/4885CASP1 2167/4885FFAR3 505/4885 |
| US-20230181555-A1 | STABLE AND PRESERVED PHARMACEUTICAL COMPOSITIONS OF BILASTINE | HRH4, CNR2, CNR1 | CA4 509/4885CASP1 2616/4885FFAR3 328/4885 |
| US-11642309-B2 | Aqueous compositions comprising bilastine and mometasone | HRH4, HRH2, HRH1 | CA4 955/4885CASP1 2167/4885FFAR3 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.