Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657282 | 1.00 | KDM4E (0.36) | KDM4EMAPTALDH1A1GSK3BKCNJ6 | |
| SCHEMBL3655458 | 0.93 | KDM4E (0.34) | KDM4EMAPTALDH1A1GSK3BKCNJ6 | |
| SCHEMBL3030717 | 0.85 | KDM4E (0.36) | KDM4EMAPTALDH1A1GSK3BKCNJ6 | |
| SCHEMBL3030724 | 0.85 | KDM4E (0.36) | KDM4EMAPTALDH1A1GSK3BKCNJ6 | |
| SCHEMBL3650704 | 0.83 | SMPD1 (0.37) | KDM4EMAPTGSK3BKCNJ6KCNJ5 | |
| SCHEMBL3021544 | 0.83 | KDM4E (0.34) | KDM4EMAPTALDH1A1GSK3BKCNJ6 | |
| SCHEMBL3656602 | 0.83 | JAK2 (0.39) | GSK3BRPS6KA3JAK2LMNAKCNH2 | |
| SCHEMBL3651526 | 0.79 | SRC (0.37) | JAK2LMNASMN1; SMN2 | |
| SCHEMBL3651523 | 0.79 | SRC (0.37) | JAK2LMNASMN1; SMN2 | |
| SCHEMBL3032363 | 0.79 | KDM4E (0.34) | KDM4EMAPTALDH1A1GSK3BKCNJ6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212309-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | Janssen Pharmaceutica N.V. (BE) | 2010-08-04 | — | — | EP | claimed |
| WO-2009050186-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-23 | — | — | WO | claimed |
| EP-2212309-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | Janssen Pharmaceutica N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009050186-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-23 | — | — | WO | disclosed |