Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | STAT5A | P42229 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | CDKL1 | Q00532 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014873 | 0.86 | JAK2 (0.38) | JAK2CDK4CDK2TDO2GSK3B | |
| SCHEMBL3014868 | 0.86 | JAK2 (0.38) | JAK2CDK4CDK2TDO2GSK3B | |
| SCHEMBL3657283 | 0.83 | KDM4E (0.36) | JAK2LMNAGSK3BKCNH2RPS6KA3 | |
| SCHEMBL3657282 | 0.83 | KDM4E (0.36) | JAK2LMNAGSK3BKCNH2RPS6KA3 | |
| SCHEMBL3655261 | 0.81 | JAK2 (0.42) | JAK2CDK4CDK2SRCPDGFRA | |
| SCHEMBL3655264 | 0.81 | JAK2 (0.42) | JAK2CDK4CDK2SRCPDGFRA | |
| SCHEMBL3655458 | 0.78 | KDM4E (0.34) | JAK2GSK3BRPS6KA3 | |
| SCHEMBL3025071 | 0.77 | PSEN1 (0.38) | JAK2CDK4CDK2TDO2GSK3B | |
| SCHEMBL862180 | 0.77 | TDO2 (0.49) | CDK4CDK2SRCTDO2GSK3B | |
| SCHEMBL827665 | 0.75 | STK17A (0.49) | CDK4CDK2SRCTDO2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212309-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | Janssen Pharmaceutica N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009050186-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-23 | — | — | WO | disclosed |