Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2068257 | 0.85 | ROCK1 (0.47) | ROCK1ROCK2LMNASMN1; SMN2 | |
| SCHEMBL3651090 | 0.84 | ROCK1 (0.47) | ROCK1CSNK2A1ROCK2RAB9A | |
| SCHEMBL3657740 | 0.83 | ROCK1 (0.45) | ROCK1ROCK2LMNASMN1; SMN2 | |
| SCHEMBL3653730 | 0.82 | ROCK2 (0.60) | ROCK1CSNK2A1ROCK2LMNA | |
| SCHEMBL3648974 | 0.81 | MEN1 (0.46) | ROCK1CSNK2A1ROCK2LMNARAB9A | |
| SCHEMBL3651578 | 0.79 | ROCK1 (0.64) | ROCK1CSNK2A1ROCK2RAB9A | |
| SCHEMBL4781259 | 0.74 | SCD (0.53) | ROCK1CSNK2A1ROCK2LMNARAB9A | |
| SCHEMBL3653464 | 0.74 | CSNK2A1 (0.43) | ROCK1CSNK2A1ROCK2LMNARAB9A | |
| SCHEMBL352380 | 0.73 | ROCK1 (0.39) | ROCK1ROCK2LMNARAB9A | |
| SCHEMBL354220 | 0.73 | ROCK1 (0.38) | ROCK1ROCK2LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | claimed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | claimed |
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | disclosed |