Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | PDE8A | O60658 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | PDE8B | O95263 | 1/20 | 0.38 |
| ▸ | PDE6A | P16499 | 1/20 | 0.38 |
| ▸ | PDE6G | P18545 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE6B | P35913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658183 | 0.83 | PDE10A (0.55) | PDE10APDE2ATP53HTR2CPDE6D | |
| SCHEMBL3658809 | 0.79 | PDE10A (0.54) | PDE10APDE2ATP53ALDH1A1HPGD | |
| SCHEMBL970421 | 0.78 | PDE10A (0.71) | PDE10APDE2AALDH1A1HPGDKMT2A | |
| SCHEMBL3795533 | 0.77 | PDE10A (0.60) | PDE10APDE2APDE5APDE3A | |
| SCHEMBL969869 | 0.77 | PDE10A (0.58) | PDE10APDE2APDE6DPDE8APDE5A | |
| SCHEMBL968378 | 0.74 | PDE10A (0.58) | PDE10APDE2AALDH1A1HPGDKMT2A | |
| SCHEMBL970002 | 0.74 | PDE10A (0.58) | PDE10APDE2AALDH1A1HPGDKMT2A | |
| SCHEMBL3658185 | 0.73 | PDE10A (0.41) | PDE10APDE2ATP53MAPTHTR2C | |
| SCHEMBL972333 | 0.73 | RPS6KA5 (0.47) | PDE10APDE2APDE6DPDE8APDE5A | |
| SCHEMBL3661029 | 0.72 | PDE10A (0.61) | PDE10APDE2ATP53ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225248-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | Wyeth LLC (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009070584-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2009-06-04 | — | — | WO | disclosed |