Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.55 |
| ▸ | PDE2A | O00408 | 7/20 | 0.46 |
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | PDE8A | O60658 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | PDE6A | P16499 | 1/20 | 0.41 |
| ▸ | PDE6G | P18545 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE6B | P35913 | 1/20 | 0.41 |
| ▸ | PDE6C | P51160 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795533 | 0.95 | PDE10A (0.60) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL3661029 | 0.91 | PDE10A (0.61) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL3662037 | 0.87 | PDE10A (0.61) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL3658185 | 0.85 | PDE10A (0.41) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL3657931 | 0.83 | PDE10A (0.47) | PDE10APDE2APDE5APDE3ATP53 | |
| SCHEMBL3658809 | 0.81 | PDE10A (0.54) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL969869 | 0.80 | PDE10A (0.58) | PDE10APDE2APDE5APDE3APDE6D | |
| SCHEMBL3655166 | 0.78 | PDE2A (0.58) | PDE10APDE2APDE7A | |
| SCHEMBL3657322 | 0.77 | PDE10A (0.54) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL972979 | 0.75 | PDE10A (0.57) | PDE10APDE2APDE5APDE3APDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227472-A1 | ARYL AND HETEROARYL FUSED IMIDAZO (1,5-A) PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | Elbion Gmbh (DE) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068320-A1 | ARYL AND HETEROARYL FUSED IMIDAZO (1,5-A) PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | ELBION GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |