Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 4/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651773 | 0.93 | MT-CO2 (0.40) | MT-CO2GAAPPARAPOLBF2 | |
| SCHEMBL3653869 | 0.85 | MT-CO2 (0.42) | MT-CO2GAAF2TSHRCA14 | |
| SCHEMBL3650899 | 0.83 | MT-CO2 (0.44) | MT-CO2GAAF2 | |
| SCHEMBL3649754 | 0.82 | MT-CO2 (0.43) | MT-CO2GAAF2CA14 | |
| SCHEMBL3653260 | 0.82 | MT-CO2 (0.40) | MT-CO2GAAF2TMEM97SIGMAR1 | |
| SCHEMBL3657533 | 0.81 | MT-CO2 (0.46) | MT-CO2GAAF2MAPTNPSR1 | |
| SCHEMBL3654081 | 0.81 | MT-CO2 (0.40) | MT-CO2GAAPOLBF2STS | |
| SCHEMBL3660212 | 0.80 | GAA (0.46) | MT-CO2GAAMAPTTSHR | |
| SCHEMBL3653328 | 0.79 | MT-CO2 (0.45) | MT-CO2GAAPOLBF2TSHR | |
| SCHEMBL3650692 | 0.79 | MT-CO2 (0.43) | MT-CO2GAAF2STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201012-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | AstraZeneca AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009047563-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |