Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 6/20 | 0.53 |
| ▸ | CDK9 | P50750 | 6/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30507501 | 0.86 | CDK2 (0.52) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL28512792 | 0.86 | GSK3B (0.60) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL30507464 | 0.86 | GSK3B (0.60) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL28497712 | 0.86 | CDK2 (0.52) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL31011620 | 0.85 | HSP90AA1 (0.45) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL31011609 | 0.85 | HSP90AA1 (0.45) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL30507254 | 0.85 | CHRNA7 (0.55) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL15939816 | 0.85 | CHRNA7 (0.55) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL30507329 | 0.81 | HSP90AA1 (0.60) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL3362587 | 0.81 | HSP90AA1 (0.60) | CCNT1CDK9CDK5CDK5R1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |