Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104236 | 0.79 | BTK (0.84) | BTK | |
| SCHEMBL3658579 | 0.77 | BTK (0.55) | BTKNR1H4PPARGRAB9ASMN1; SMN2 | |
| SCHEMBL4183020 | 0.76 | BTK (0.49) | BTKNR1H4PPARGRAB9ASMN1; SMN2 | |
| SCHEMBL3959742 | 0.76 | RAB9A (0.52) | BTKNR1H4PPARGRAB9ASMN1; SMN2 | |
| SCHEMBL3870962 | 0.75 | BTK (0.70) | BTKNR1H4PPARGRAB9ASMN1; SMN2 | |
| SCHEMBL3953320 | 0.75 | BTK (0.48) | BTKNR1H4PPARGRAB9ASMN1; SMN2 | |
| SCHEMBL4086768 | 0.74 | BTK (0.61) | BTKNR1H4PPARGRAB9ASMN1; SMN2 | |
| SCHEMBL4085005 | 0.74 | BTK (0.61) | BTK | |
| SCHEMBL3955908 | 0.72 | BTK (0.45) | BTKNR1H4PPARGRAB9ASMN1; SMN2 | |
| SCHEMBL3963719 | 0.71 | BTK (0.51) | BTKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205564-A1 | NOVEL KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |