Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 7/20 | 0.36 |
| ▸ | KMO | O15229 | 5/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | ULK1 | O75385 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657778 | 0.94 | KMO (0.36) | EIF4EKMO | |
| SCHEMBL3656807 | 0.88 | KMO (0.39) | KMOSYKKDM4C | |
| SCHEMBL3659897 | 0.88 | NR3C2 (0.37) | — | |
| SCHEMBL3803786 | 0.83 | MRGPRX4 (0.37) | KMOKDM4CULK1 | |
| SCHEMBL3658227 | 0.81 | MDM4 (0.38) | SYK | |
| SCHEMBL3657608 | 0.80 | EIF4E (0.36) | EIF4EKMOSYKPPARGKDM4C | |
| SCHEMBL3658104 | 0.76 | MRGPRX4 (0.42) | KMOKDM4C | |
| SCHEMBL3659842 | 0.74 | KMO (0.36) | EIF4EKMO | |
| SCHEMBL837922 | 0.73 | KMO (0.37) | EIF4EKMOSYKPPARG | |
| SCHEMBL3658899 | 0.72 | NR1H4 (0.37) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | claimed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | claimed |
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |