SCHEMBL3658624

SCHEMBL3658624

Cn1c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CCSCC4(O)O)cc3)ncc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 10/20 0.55
TTK P33981 3/20 0.49
CSF1R P07333 1/20 0.49
CCNA2 P20248 4/20 0.49
CDK2 P24941 4/20 0.49
AURKA O14965 2/20 0.49
CDK4 P11802 9/20 0.47
CCND1 P24385 9/20 0.47
CCND2 P30279 6/20 0.47
CCND3 P30281 6/20 0.47
CCNE2 O96020 3/20 0.47
CCNE1 P24864 3/20 0.47
CCNA1 P78396 3/20 0.47
PAK4 O96013 1/20 0.47
PAK1 Q13153 1/20 0.47
PKN1 Q16512 1/20 0.47
CCNB2 O95067 3/20 0.46
CDK1 P06493 3/20 0.46
CCNB1 P14635 3/20 0.46
CCNB3 Q8WWL7 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1781620 0.81 CDK4 (0.68) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1782576 0.80 CDK4 (0.67) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1781331 0.80 CDK4 (0.71) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1781854 0.78 PRKDC (0.59) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1781852 0.77 CDK4 (0.62) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1782804 0.76 PRKDC (0.69) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1780821 0.76 PRKDC (0.63) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1782006 0.76 PRKDC (0.60) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1781375 0.75 PRKDC (0.71) PRKDCTTKCSF1RCCNA2CDK2
SCHEMBL1781846 0.75 PRKDC (0.62) PRKDCTTKCSF1RCCNA2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2212326-A1 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS AstraZeneca AB (SE) 2010-08-04 EP disclosed
WO-2009024824-A1 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS ASTRAZENECA AB (SE) 2009-02-26 WO disclosed