Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300293 | 0.91 | METTL3 (0.61) | METTL3PDE10AGSK3BPOLBKDM4E | |
| SCHEMBL1300296 | 0.91 | METTL3 (0.61) | METTL3PDE10AGSK3BPOLBKDM4E | |
| SCHEMBL3660161 | 0.83 | METTL3 (0.38) | METTL3PDE10AGSK3BKDM4EMEN1 | |
| SCHEMBL1301634 | 0.83 | METTL3 (0.55) | METTL3PDE10AGSK3BPOLBKDM4E | |
| SCHEMBL1301640 | 0.83 | METTL3 (0.55) | METTL3PDE10AGSK3BPOLBKDM4E | |
| SCHEMBL1302090 | 0.78 | TOP1 (0.41) | METTL3PDE10APOLBKDM4EMEN1 | |
| SCHEMBL1302092 | 0.78 | TOP1 (0.41) | METTL3PDE10APOLBKDM4EMEN1 | |
| SCHEMBL1300490 | 0.78 | METTL3 (0.57) | METTL3PDE10AKDM4ETOP1HPGD | |
| SCHEMBL1300493 | 0.78 | METTL3 (0.57) | METTL3PDE10AKDM4ETOP1HPGD | |
| SCHEMBL1301595 | 0.77 | METTL3 (0.57) | METTL3PDE10APOLBKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231665-A2 | NOVEL COMPOSITIONS AND METHODS OF USE | Ardea Biosciences, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009089263-A2 | NOVEL COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES INC. (US) | 2009-07-16 | — | — | WO | claimed |