Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302681 | 0.79 | NOS1 (0.39) | GLAL3MBTL1NOS1MAPTKDM4E | |
| SCHEMBL6968276 | 0.79 | MAPT (0.41) | GLAL3MBTL1NOS1MAPTPTK2 | |
| SCHEMBL3007529 | 0.78 | GLA (0.50) | GLAL3MBTL1NOS1CDK5CDK2 | |
| Hydrochloric Acid SCHEMBL6977242 | 0.78 | MAPT (0.40) | GLAL3MBTL1NOS1MAPTPTK2 | |
| SCHEMBL6964834 | 0.76 | MAPT (0.35) | GLAL3MBTL1NOS1MAPT | |
| SCHEMBL3008793 | 0.75 | GLA (0.47) | GLAL3MBTL1NOS1CDK5CDK2 | |
| SCHEMBL20239491 | 0.73 | GLA (0.63) | GLAL3MBTL1NOS1CDK5CDK2 | |
| SCHEMBL21863628 | 0.73 | GLA (0.58) | GLAL3MBTL1NOS1CDK5CDK2 | |
| SCHEMBL29520983 | 0.69 | GLA (0.54) | GLAL3MBTL1NOS1CDK5CDK2 | |
| SCHEMBL27762041 | 0.69 | GLA (0.54) | GLAL3MBTL1NOS1CDK5CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227464-A1 | DERIVATIVES OF 1-[(IMIDAZOLIDIN-2-YL)IMINO)]INDAZOLE | Imperial Innovations Limited (GB) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009071906-A1 | DERIVATIVES OF 1-[(IMIDAZOLIDIN-2-YL)IMINO)]INDAZOLE | IMPERIAL INNOVATIONS LIMITED (GB) | 2009-06-11 | — | — | WO | disclosed |