Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | FAP | Q12884 | 3/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27716149 | 1.00 | DPP4 (0.35) | DPP4FAPPREPRAB9AHCRTR2 | |
| SCHEMBL3150565 | 0.81 | HSD17B10 (0.46) | HCRTR2ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL2685303 | 0.81 | HSD17B10 (0.46) | HCRTR2ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL18007258 | 0.80 | HSD17B10 (0.36) | DPP4FAPPREPRAB9AHCRTR2 | |
| SCHEMBL2586890 | 0.80 | HSD17B10 (0.36) | DPP4FAPPREPRAB9AHCRTR2 | |
| SCHEMBL25308238 | 0.80 | TSHR (0.31) | — | |
| SCHEMBL461662 | 0.78 | DPP4 (0.35) | DPP4FAPPREPRAB9AHCRTR2 | |
| SCHEMBL18173562 | 0.76 | RAB9A (0.35) | DPP4FAPPREPRAB9AHCRTR2 | |
| SCHEMBL1906745 | 0.73 | GAA (0.33) | DPP4FAPPREPRAB9AHCRTR2 | |
| SCHEMBL15690708 | 0.72 | TP53 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205559-A1 | RENIN INHIBITORS | Cadila Healthcare Limited (IN) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009087649-A1 | RENIN INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2009-07-16 | — | — | WO | disclosed |