Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.86 |
| ▸ | GRM6 | O15303 | 2/20 | 0.86 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.86 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.86 |
| ▸ | GSR | P00390 | 2/20 | 0.86 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.86 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.86 |
| ▸ | GRM5 | P41594 | 1/20 | 0.86 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.86 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.86 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.86 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.86 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.86 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.86 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.86 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.86 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.86 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL28753756 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL14742420 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL19348258 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL19348263 | 0.94 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL28325695 | 0.94 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL28980361 | 0.93 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1330484 | 0.93 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1330824 | 0.93 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL931953 | 0.93 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL17127348 | 0.93 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104857523-A | Trastuzumab-mediated cis-platinum targeting conjugate and preparation method thereof | UNIV SOUTHEAST | 2015-08-26 | — | — | CN | claimed |
| CN-104114188-A | Composite micelle carrier medicine composition for reducing free radical damage | ORIGINAL BIOMEDICALS CO LTD | 2014-10-22 | — | — | CN | claimed |
| CN-103596558-A | polymer shell nanocapsules | UNIV SANTIAGO COMPOSTELA | 2014-02-19 | — | — | CN | claimed |
| CN-103127521-A | Drug carrier with chelating type composite micelle and application thereof | ORIGINAL BIOMEDICALS CO LTD | 2013-06-05 | — | — | CN | claimed |
| CN-101721709-A | Calcium phosphate and amphiphilic polymer composite medicament-carrying nano-microsphere, preparation method and application | SHANGHAI PESTICIDE RES INST | 2010-06-09 | — | — | CN | claimed |
| CN-112724240-A | Xenopus laevis glucagon-like peptide-1 analogue and application thereof | 江苏师范大学 | 2021-04-30 | — | — | CN | disclosed |
| WO-2019184993-A1 | COMBINATION OF POLYETHYLENE GLYCOL AND RAPAMYCIN AND USE THEREOF | 天津键凯科技有限公司 | 2019-10-03 | — | — | WO | disclosed |
| US-10391063-B2 | Pharmaceutical composition of polyethylene glycol-modified camptothecin derivative and preparation method thereof | JENKEM TECHNOLOGY CO., LTD. (TIANJIN) (CN) | 2019-08-27 | — | — | US | disclosed |
| US-10098870-B2 | Polyethylene glycol-cactus oligopeptide bonding rapamycin derivatives | JENKEM TECHNOLOGY CO., LTD. (BEIJING) (CN) | 2018-10-16 | — | — | US | disclosed |
| CN-104448295-B | The rapamycin derivative of polyethylene glycol multijaw oligopeptides bonding | 北京键凯科技股份有限公司 | 2018-01-23 | — | — | CN | disclosed |
| US-20170266305-A1 | PHARMACEUTICAL COMPOSITION OF POLYETHYLENE GLYCOL-MODIFIED CAMPTOTHECIN DERIVATIVE AND PREPARATION METHOD THEREOF | JENKEM TECHNOLOGY CO., LTD. (TIANJIN) (CN) | 2017-09-21 | — | — | US | disclosed |
| CN-103936985-B | A kind of preparation method and applications of Nano particles of polyaniline | 中国科学院长春应用化学研究所 | 2017-06-23 | — | — | CN | disclosed |
| CN-101808668-A | Active targeting type polymeric micelle carrying drug enclosed therein and medicinal composition | NANOCARRIER CO LTD | 2010-08-18 | — | — | CN | disclosed |
| CN-101808651-A | polymer conjugate of steroid | NIPPON KAYAKU KK | 2010-08-18 | — | — | CN | disclosed |
| CN-101721709-A | Calcium phosphate and amphiphilic polymer composite medicament-carrying nano-microsphere, preparation method and application | SHANGHAI PESTICIDE RES INST | 2010-06-09 | — | — | CN | disclosed |
| EP-1489125-B1 | COMPOUND OF HYDROPHILIC POLYMER-POLYCARBOXYL OLIGOPEPTIDE AND MEDICINES, MEDICAL COMPOSITE COMPRISING ABOVE COMPOUND AND USE OF ABOVE COMPOUND IN MEDICINES | BEIJING JIANKAI TECHNOLOGY CO (CN) | 2010-01-27 | — | — | EP | disclosed |
| CN-101590241-A | Cisplatin nano-micelle prodrug and preparation method thereof | SH NAT ENG RES CT NANOTECH CO (CN) | 2009-12-02 | — | — | CN | disclosed |
| CN-100344293-C | Polymeric micelle containing cisplatin enclosed therein and use thereof | CT FOR ADVANCED SCIENCE & TECH (JP) | 2007-10-24 | — | — | CN | disclosed |
| EP-1489125-A1 | COMPOUND OF HYDROPHILIC POLYMER-POLYCARBOXYL OLIGOPEPTIDE AND MEDICINES, MEDICAL COMPOSITE COMPRISING ABOVE COMPOUND AND USE OF ABOVE COMPOUND IN MEDICIMES | Beijing Jiankai Technology Co., Ltd. (CN) | 2004-12-22 | — | — | EP | disclosed |
| CN-1476330-A | Polymeric micelle encapsulating cisplatin and use thereof | ��ʽ�����ȶ˿�ѧ������������ | 2004-02-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170266305-A1 | PHARMACEUTICAL COMPOSITION OF POLYETHYLENE GLYCOL-MODIFIED CAMPTOTHECIN DERIVATIVE AND PREPARATION METHOD THEREOF | LPXN, PDE10A, PDE8A | GRM8 4646/4885GRM6 4595/4885GRM7 4718/4885 |
| US-10391063-B2 | Pharmaceutical composition of polyethylene glycol-modified camptothecin derivative and preparation method thereof | LPXN, PDE10A, PDE8A | GRM8 4646/4885GRM6 4595/4885GRM7 4718/4885 |
| US-10098870-B2 | Polyethylene glycol-cactus oligopeptide bonding rapamycin derivatives | RICTOR, RPTOR, MTOR | GRM8 2429/4885GRM6 2202/4885GRM7 1676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.