Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 13/20 | 0.57 |
| ▸ | P2RX2 | Q9UBL9 | 13/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357247 | 1.00 | P2RX3 (0.57) | P2RX3P2RX2NR1I2CYP2C9 | |
| SCHEMBL27769417 | 0.95 | P2RX3 (0.57) | P2RX3P2RX2NR1I2CYP2C9 | |
| SCHEMBL4322514 | 0.95 | P2RX3 (0.57) | P2RX3P2RX2NR1I2CYP2C9 | |
| SCHEMBL4332031 | 0.94 | P2RX3 (0.57) | P2RX3P2RX2 | |
| SCHEMBL4318813 | 0.93 | P2RX3 (0.55) | P2RX3P2RX2 | |
| SCHEMBL2271040 | 0.90 | P2RX3 (0.60) | P2RX3P2RX2 | |
| SCHEMBL10244805 | 0.89 | P2RX3 (0.59) | P2RX3P2RX2 | |
| SCHEMBL4323106 | 0.88 | P2RX3 (0.61) | P2RX3P2RX2 | |
| SCHEMBL28776965 | 0.88 | P2RX3 (0.61) | P2RX3P2RX2 | |
| SCHEMBL4323150 | 0.87 | P2RX3 (0.59) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570407-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2014-08-13 | — | — | EP | disclosed |
| EP-2234989-A1 | TETRAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077371-A1 | TETRAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |