Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL956361 | 0.88 | BACE1 (0.47) | BACE1TLR2TLR1P2RY12TGM2 | |
| SCHEMBL956359 | 0.88 | BACE1 (0.47) | BACE1TLR2TLR1P2RY12TGM2 | |
| SCHEMBL3660131 | 0.83 | BACE1 (0.40) | BACE1TSHRGAATLR2TLR1 | |
| SCHEMBL951566 | 0.81 | BACE1 (0.48) | BACE1TSHRTLR2 | |
| SCHEMBL951567 | 0.81 | BACE1 (0.48) | BACE1TSHRTLR2 | |
| SCHEMBL13702142 | 0.79 | TLR2 (0.53) | BACE1TLR2TLR1KMT2ATGM2 | |
| SCHEMBL2853531 | 0.77 | MDM2 (0.45) | BACE1TLR2TLR1KMT2A | |
| SCHEMBL2853534 | 0.77 | MDM2 (0.45) | BACE1TLR2TLR1KMT2A | |
| SCHEMBL4912763 | 0.77 | ITGB3 (0.50) | BACE1TLR2TLR1KMT2A | |
| SCHEMBL10099568 | 0.76 | MDM2 (0.47) | TLR2TLR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238128-A2 | HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009080226-A2 | HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS | SANOFIS-AVENTIS (FR) | 2009-07-02 | — | — | WO | disclosed |