Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.43 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660308 | 1.00 | HRH3 (0.53) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4305733 | 0.91 | HRH3 (0.43) | HRH3KCNH2HRH1TDP2 | |
| SCHEMBL3656956 | 0.91 | HRH3 (0.43) | HRH3KCNH2HRH1TDP2 | |
| Hydrochloric Acid SCHEMBL4309596 | 0.90 | HRH3 (0.52) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| Hydrochloric Acid SCHEMBL4309598 | 0.90 | HRH3 (0.52) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4318726 | 0.89 | HRH3 (0.49) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL3650524 | 0.89 | HRH3 (0.49) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4315124 | 0.89 | HRH3 (0.56) | HRH3KCNH2 | |
| SCHEMBL4320884 | 0.89 | HRH3 (0.55) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4320722 | 0.89 | HRH3 (0.52) | HRH3KCNH2HTR1ASLC6A4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200998-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009036117-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-19 | — | — | WO | disclosed |
| US-20090069370-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069370-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH1, HRH2 | HRH3 4/4885KCNH2 456/4885HTR1A 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.