Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.39 |
| ▸ | AHCY | P23526 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.36 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660435 | 1.00 | PI4KA (0.39) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL12170665 | 0.90 | PI4KA (0.52) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL3657560 | 0.89 | AHCY (0.38) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL3657567 | 0.89 | AHCY (0.38) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL18948228 | 0.89 | AHCY (0.38) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL3659976 | 0.87 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL3659974 | 0.87 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL3437181 | 0.87 | PRMT5 (0.44) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL3437180 | 0.87 | PRMT5 (0.44) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL7217722 | 0.87 | PRMT5 (0.44) | PI4KAPI4K2BPI4K2API4KBAHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227482-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | Pharmasset, Inc. (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009067409-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2009-05-28 | — | — | WO | claimed |
| EP-2848624-A1 | 2',4'-substituted nucleosides as antiviral agents | Gilead Pharmasset LLC (US) | 2015-03-18 | — | — | EP | disclosed |
| EP-2631239-A1 | 2',4'-substituted nucleosides as antiviral agents | Gilead Pharmasset LLC (US) | 2013-08-28 | — | — | EP | disclosed |