SCHEMBL3660622

SCHEMBL3660622

CC(CC(C)(N)C(F)(F)F)c1ccncc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.37
CYP2C9 P11712 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
CYP3A4 P08684 3/20 0.36
AAK1 Q2M2I8 3/20 0.36
SLC6A2 P23975 2/20 0.33
SLC6A4 P31645 2/20 0.33
SLC6A3 Q01959 2/20 0.33
CYP2C19 P33261 2/20 0.33
PDE2A O00408 1/20 0.33
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14889555 0.82 CYP3A4 (0.38) HDAC3CYP2C9HDAC4HDAC1HDAC7
SCHEMBL17703537 0.77 CYP3A4 (0.40) CYP3A4SLC6A2SLC6A4SLC6A3CYP2C19
SCHEMBL16296471 0.77 HDAC3 (0.41) HDAC3CYP2C9HDAC4HDAC1HDAC7
SCHEMBL6265732 0.69 SLC6A2 (0.42) SLC6A2SLC6A4SLC6A3GAAALDH1A1
SCHEMBL11728032 0.69 TAAR1 (0.60) CYP3A4SLC6A2SLC6A4SLC6A3CYP2C19
SCHEMBL9586848 0.68 SLC6A2 (0.41) SLC6A2SLC6A4SLC6A3CYP2C19GAA
SCHEMBL23956932 0.66 TAAR1 (0.39) CYP2C9CYP3A4SLC6A2SLC6A4SLC6A3
SCHEMBL17469429 0.66 CYP3A4 (0.44) CYP2C9CYP3A4SLC6A2SLC6A4SLC6A3
SCHEMBL10031596 0.66 CYP3A4 (0.44) CYP2C9CYP3A4SLC6A2SLC6A4SLC6A3
SCHEMBL117057 0.66 CYP3A4 (0.44) CYP2C9CYP3A4SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2203160-A1 PHARMACOLOGICAL ADJUNCTIVE TREATMENT ASSOCIATED WITH GLAUCOMA FILTRATION SURGERY Bausch & Lomb Incorporated (US) 2010-07-07 EP disclosed
WO-2009042377-A1 PHARMACOLOGICAL ADJUNCTIVE TREATMENT ASSOCIATED WITH GLAUCOMA FILTRATION SURGERY BAUSCH & LOMB INCORPORATED (US) 2009-04-02 WO disclosed