Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019329 | 0.87 | RIPK1 (0.52) | SLC6A3TAAR1RIPK1ALDH1A1MAPK1 | |
| SCHEMBL9586848 | 0.85 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3GAATAAR1 | |
| SCHEMBL19820873 | 0.82 | RIPK1 (0.41) | SLC6A2SLC6A4SLC6A3GAATAAR1 | |
| SCHEMBL17703537 | 0.77 | CYP3A4 (0.40) | SLC6A2SLC6A4SLC6A3GAATAAR1 | |
| SCHEMBL9588265 | 0.77 | RIPK1 (0.59) | SLC6A2SLC6A4SLC6A3GAATAAR1 | |
| SCHEMBL19820880 | 0.76 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3GAATAAR1 | |
| SCHEMBL14889555 | 0.74 | CYP3A4 (0.38) | SLC6A2SLC6A4SLC6A3GAATAAR1 | |
| SCHEMBL20097983 | 0.74 | KIF11 (0.39) | KIF11 | |
| SCHEMBL21524663 | 0.74 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3GAATAAR1 | |
| SCHEMBL19670976 | 0.74 | TAAR1 (0.50) | SLC6A2SLC6A4SLC6A3TAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144372-B1 | SULPHOHYDROXAMIC ACIDS AND SULPHOHYDROXAMATES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |