⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12850809 | 1.00 | — | — | |
| SCHEMBL18430371 | 0.79 | — | — | |
| SCHEMBL21000177 | 0.79 | — | — | |
| SCHEMBL19545530 | 0.79 | EZH2 (0.35) | — | |
| SCHEMBL8191606 | 0.78 | — | — | |
| SCHEMBL765223 | 0.76 | — | — | |
| SCHEMBL20776469 | 0.74 | — | — | |
| SCHEMBL21072550 | 0.73 | CYP2D6 (0.35) | — | |
| SCHEMBL16404862 | 0.72 | — | — | |
| SCHEMBL20773949 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836494-B1 | NEW ALKYLATING AGENTS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2019-08-21 | — | — | EP | disclosed |
| EP-3049420-B1 | THIENO[2,3-E]INDOLE DERIVATIVES AS NEW ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2019-05-15 | — | — | EP | disclosed |
| US-20170312290-A1 | FUNCTIONALIZED MORPHOLINYL ANTHRACYCLINE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-11-02 | — | — | US | disclosed |
| US-20170071907-A1 | THIENO-INDOLE MOIETIES AND METHODS OF TREATING USING THE SAME | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-03-16 | — | — | US | disclosed |
| US-20170071907-A1 | THIENO-INDOLE MOIETIES AND METHODS OF TREATING USING THE SAME | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-03-16 | — | — | US | disclosed |
| US-9556192-B2 | Functionalized 9-bromo-camptothecin derivatives | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-01-31 | — | — | US | disclosed |
| WO-2016071418-A1 | FUNCTIONALIZED MORPHOLINYL ANTHRACYCLINE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-05-12 | — | — | WO | disclosed |
| US-8278454-B2 | Process for preparing tetrahydroquinoline derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-10-02 | — | — | US | disclosed |
| US-8278454-B2 | Process for preparing tetrahydroquinoline derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-10-02 | — | — | US | disclosed |
| US-8278454-B2 | Process for preparing tetrahydroquinoline derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-10-02 | — | — | US | disclosed |
| US-20100311976-A1 | PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100311976-A1 | PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100311976-A1 | PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-12-09 | — | — | US | disclosed |
| EP-2220067-A2 | PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES | Merck Patent GmbH (DE) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009077052-A2 | PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009077052-A2 | PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-06-25 | — | — | WO | disclosed |