Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660838 | 1.00 | KDM1A (0.45) | KDM1AMAOBRAB9ANPC1SLC6A2 | |
| SCHEMBL3184354 | 0.92 | SLC6A2 (0.48) | KDM1AMAOBRAB9ANPC1SLC6A2 | |
| SCHEMBL3184339 | 0.92 | SLC6A2 (0.48) | KDM1AMAOBRAB9ANPC1SLC6A2 | |
| SCHEMBL3184345 | 0.92 | SLC6A2 (0.48) | KDM1AMAOBRAB9ANPC1SLC6A2 | |
| SCHEMBL3195739 | 0.88 | KDM1A (0.58) | KDM1AMAOBSLC6A2LMNAHDAC6 | |
| SCHEMBL3197346 | 0.88 | KDM1A (0.58) | KDM1AMAOBSLC6A2LMNAHDAC6 | |
| SCHEMBL3197364 | 0.88 | KDM1A (0.58) | KDM1AMAOBSLC6A2LMNAHDAC6 | |
| SCHEMBL3195721 | 0.88 | KDM1A (0.58) | KDM1AMAOBSLC6A2LMNAHDAC6 | |
| SCHEMBL3195727 | 0.88 | KDM1A (0.58) | KDM1AMAOBSLC6A2LMNAHDAC6 | |
| SCHEMBL3185240 | 0.81 | RAB9A (0.46) | KDM1AMAOBRAB9ANPC1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142505-A1 | SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer, Inc. (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008120093-A1 | SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 2008-10-09 | — | — | WO | disclosed |