Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 11/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660945 | 0.93 | PDE11A (0.44) | PDE11ATACR3HPGDMCL1ADORA2A | |
| SCHEMBL3347230 | 0.71 | CHEK2 (0.41) | HPGDHDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL28139104 | 0.70 | PDPK1 (0.40) | NPC1RAB9A | |
| SCHEMBL28843050 | 0.70 | PLA2G2A (0.44) | NPC1RAB9A | |
| SCHEMBL3350744 | 0.68 | HPGD (0.37) | HPGDNPC1RAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3349083 | 0.67 | HPGD (0.36) | HPGDNPC1RAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3351578 | 0.67 | HPGD (0.36) | HPGDNPC1RAB9AMEN1KMT2A | |
| SCHEMBL13957931 | 0.64 | TACR3 (0.62) | TACR3HPGDNPC1RAB9AMEN1 | |
| SCHEMBL13729456 | 0.64 | PDPK1 (0.40) | HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL28255768 | 0.64 | FFAR1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |