Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.32 |
| ▸ | GPR39 | O43194 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664633 | 0.90 | NPSR1 (0.37) | NPSR1RXFP1ALDH1A1LMNAKDM4E | |
| SCHEMBL3665505 | 0.85 | ESR1 (0.37) | NPSR1RXFP1ALDH1A1LMNAPTPN7 | |
| SCHEMBL3663869 | 0.76 | GRM5 (0.36) | NPSR1RXFP1ALDH1A1LMNAKDM4E | |
| SCHEMBL3664991 | 0.76 | MDM2 (0.41) | NPSR1RXFP1ALDH1A1LMNAMAPT | |
| SCHEMBL4183866 | 0.74 | CYP2A6 (0.36) | NPSR1RXFP1ALDH1A1LMNAKDM4E | |
| SCHEMBL3667875 | 0.69 | GPR39 (0.37) | NPSR1RXFP1ALDH1A1LMNAKDM4E | |
| SCHEMBL3663765 | 0.66 | CCR1 (0.40) | NPSR1RXFP1ALDH1A1LMNAKDM4E | |
| SCHEMBL3663615 | 0.65 | CCR1 (0.37) | NPSR1RXFP1ALDH1A1LMNAKDM4E | |
| SCHEMBL3661769 | 0.65 | KDM4E (0.37) | NPSR1RXFP1ALDH1A1LMNAKDM4E | |
| SCHEMBL3659080 | 0.65 | CYP1A2 (0.45) | NPSR1RXFP1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242742-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009087212-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |