Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662765 | 0.90 | NPC1 (0.43) | NPC1RAB9AALDH1A1ALOX15MAPT | |
| SCHEMBL3481086 | 0.78 | NPC1 (0.51) | CCKARNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL13113411 | 0.78 | NPC1 (0.51) | CCKARNPC1RAB9AALDH1A1ALOX15 | |
| SCHEMBL219324 | 0.78 | PDGFRB (0.59) | NPC1RAB9AALDH1A1ALOX15MAPT | |
| Hydrochloric Acid SCHEMBL11881983 | 0.76 | PDGFRB (0.58) | NPC1RAB9AALDH1A1ALOX15MAPT | |
| Hydrochloric Acid SCHEMBL29522997 | 0.76 | PDGFRB (0.58) | NPC1RAB9AALDH1A1ALOX15MAPT | |
| Benzene SCHEMBL28101215 | 0.76 | PDGFRB (0.58) | NPC1RAB9AALDH1A1ALOX15MAPT | |
| Ammonia Solution, Strong SCHEMBL1598970 | 0.76 | PDGFRB (0.58) | NPC1RAB9AALDH1A1ALOX15MAPT | |
| Ethane SCHEMBL27318292 | 0.76 | PDGFRB (0.58) | NPC1RAB9AALDH1A1ALOX15MAPT | |
| Ethylene SCHEMBL27787596 | 0.75 | PDGFRB (0.56) | NPC1RAB9AALDH1A1ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215074-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | The United States of America, as Represented by the Secretary, Department of Health and Human Services (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |