Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 5/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 4/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025015 | 0.92 | FGFR3 (0.49) | FGFR3FGFR1FYNCDK8KDR | |
| SCHEMBL3025051 | 0.88 | CDK8 (0.49) | FGFR3FGFR1FYNCDK8KDR | |
| SCHEMBL3653363 | 0.86 | HDAC6 (0.45) | FGFR3FGFR1FYNCDK8KDR | |
| SCHEMBL29450856 | 0.75 | JMJD6 (0.38) | KDM4CPIK3C3NTRK1 | |
| SCHEMBL837839 | 0.75 | FGFR1 (0.65) | FGFR3FGFR1FYNCDK8HDAC8 | |
| SCHEMBL15176490 | 0.74 | NAMPT (0.47) | HDAC8HDAC6SYKPIK3C3ADRA2A | |
| SCHEMBL837898 | 0.74 | CDK8 (0.55) | FGFR3FGFR1FYNCDK8KDR | |
| SCHEMBL3030841 | 0.73 | ATM (0.57) | FGFR3FGFR1FYNKDRATM | |
| SCHEMBL13336647 | 0.73 | KDR (0.65) | FGFR3FGFR1FYNKDRATM | |
| SCHEMBL3033146 | 0.72 | KDR (0.56) | FGFR3FGFR1FYNKDRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212323-A2 | IMIDAZO [1,2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009050183-A2 | IMIDAZO [1, 2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS | NOVARTIS AG (CH) | 2009-04-23 | — | — | WO | disclosed |