Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27862873 | 0.80 | CA1 (0.51) | KDM4EALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL29502645 | 0.79 | KDM4E (0.42) | KDM4EMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28605998 | 0.76 | IDH1 (0.42) | KDM4EMAPK1HSD17B10ALDH1A1HPGD | |
| SCHEMBL27798554 | 0.75 | KMT2A (0.48) | KDM4EMAPK1HSD17B10ALDH1A1KMT2A | |
| SCHEMBL1788322 | 0.74 | KDM4E (0.46) | KDM4EMAPK1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL1788016 | 0.71 | KDM4E (0.47) | KDM4EMAPK1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11093560 | 0.71 | KDM4E (0.62) | KDM4EMAPK1HSD17B10ALDH1A1KMT2A | |
| SCHEMBL670174 | 0.71 | AURKA (0.53) | MAPK1MAPTEGFR | |
| SCHEMBL28129515 | 0.71 | KDM4E (0.44) | KDM4EKMT2AMEN1TDP1TSHR | |
| SCHEMBL118131 | 0.70 | SMN1; SMN2 (0.49) | KDM4EMAPK1HSD17B10ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2237669-A2 | CHEMICAL COMPOUNDS | Syngenta Limited (GB) | 2010-10-13 | — | — | EP | disclosed |
| EP-2235037-A1 | STEROID DERIVATIVES ACTING AS GLUCOCORTICOSTEROID RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009081112-A2 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009082342-A1 | STEROID DERIVATIVES ACTING AS GLUCOCORTICOSTEROID RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |