SCHEMBL366269

SCHEMBL366269

C[Si](C)(C)ON1CCCC1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.43
BRD2 P25440 1/20 0.43
PIK3CD O00329 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.33
LMNA P02545 3/20 0.32
CYP2D6 P10635 2/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
MAPT P10636 1/20 0.31
THRB P10828 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
RECQL P46063 1/20 0.31
BLM P54132 1/20 0.31
KMT2A Q03164 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA3 P07451 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6008423 0.82 BRD4 (0.39) BRD4BRD2PIK3CDL3MBTL1
SCHEMBL5962649 0.75
SCHEMBL6122067 0.74 BRD4 (0.46) BRD4BRD2PIK3CDLMNACYP2D6
SCHEMBL2930849 0.74 BRD4 (0.46) BRD4BRD2PIK3CDLMNACYP2D6
Hydrochloric Acid SCHEMBL27444266 0.73
Ammonia Solution, Strong SCHEMBL29140490 0.73
SCHEMBL15161544 0.71 BRD4 (0.44) BRD4BRD2PIK3CDL3MBTL1LMNA
SCHEMBL5178300 0.70
SCHEMBL4635601 0.70
SCHEMBL1027741 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012009372-A2 TRIAZOLIUM CARBENE CATALYSTS AND PROCESSES FOR ASYMMETRIC CARBON-CARBON BOND FORMATION COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2012-01-19 WO disclosed