Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842206 | 1.00 | KMT2A (0.33) | KMT2AMAPTKDM4ETDP1JAK2 | |
| SCHEMBL13929317 | 0.94 | MEN1 (0.36) | KMT2AP2RX3MEN1AMY1AALDH1A1 | |
| SCHEMBL699140 | 0.89 | PTGDR2 (0.39) | KMT2AMAPTKDM4ETDP1JAK2 | |
| SCHEMBL13929371 | 0.89 | KMT2A (0.34) | KMT2AMAPTKDM4ETDP1JAK2 | |
| SCHEMBL699507 | 0.88 | FBP1 (0.38) | KMT2AMAPTKDM4ETDP1JAK2 | |
| SCHEMBL1738979 | 0.87 | KMT2A (0.34) | KMT2AMAPTKDM4ETDP1JAK2 | |
| SCHEMBL13929367 | 0.86 | KMT2A (0.33) | KMT2AMAPTKDM4ETDP1JAK2 | |
| SCHEMBL3663350 | 0.85 | IDO1 (0.40) | KMT2AKDM4EMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3662827 | 0.84 | KMT2A (0.34) | KMT2AMAPTKDM4ETDP1JAK2 | |
| SCHEMBL7841390 | 0.84 | KMT2A (0.38) | KMT2AMAPTKDM4ETDP1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235017-A1 | SPIROINDOLINONE DERIVATIVES AS ANTICANCER AGENTS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009080488-A1 | SPIROINDOLINONE DERIVATIVES AS ANTICANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-02 | — | — | WO | disclosed |