Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.71 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.71 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.61 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.61 |
| ▸ | NNMT | P40261 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 4/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224294 | 0.89 | FYN (0.72) | MKNK1MKNK2FYNCHEK2KCNH2 | |
| SCHEMBL19127315 | 0.87 | HSD17B1 (0.62) | MKNK1MKNK2HSD17B1HSD17B2MEN1 | |
| SCHEMBL1417104 | 0.85 | MKNK1 (0.55) | MKNK1MKNK2HSD17B1HSD17B2NNMT | |
| SCHEMBL1417105 | 0.84 | MEN1 (0.81) | MKNK1MKNK2MEN1KMT2AKEAP1 | |
| SCHEMBL15849565 | 0.83 | HSD17B2 (0.58) | MKNK1MKNK2HSD17B1HSD17B2MEN1 | |
| SCHEMBL13702343 | 0.83 | MEN1 (0.63) | MKNK1MKNK2HSD17B1HSD17B2MEN1 | |
| SCHEMBL3657605 | 0.82 | FYN (0.57) | MKNK1MKNK2FYNCCNT1CCND1 | |
| SCHEMBL13702112 | 0.81 | MEN1 (0.61) | MKNK1MKNK2HSD17B1HSD17B2MEN1 | |
| SCHEMBL12269997 | 0.81 | CCNT1 (0.55) | MKNK1MKNK2FYNCCNT1CCND1 | |
| SCHEMBL1570122 | 0.81 | MKNK1 (0.68) | MKNK1MKNK2HSD17B1HSD17B2NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642788-B2 | Activators of executioner procaspases 3, 6 and 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-04 | — | — | US | disclosed |
| EP-2237784-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | The Regents of the University of California (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009089508-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | WO | disclosed |