Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717407 | 0.85 | CKS1B (0.53) | CHEK1CHEK2CKS1BSKP1SKP2 | |
| SCHEMBL3723058 | 0.84 | KIT (0.48) | CCNCCDK8CDK19JAK3 | |
| SCHEMBL4178231 | 0.84 | CHEK1 (0.58) | CHEK1CHEK2LMNAMAPTCCNC | |
| Hydrochloric Acid SCHEMBL3716314 | 0.82 | CHEK1 (0.57) | CHEK1CHEK2LMNAMAPTCCNC | |
| Hydrochloric Acid SCHEMBL3714080 | 0.82 | CHEK1 (0.57) | CHEK1CHEK2LMNAMAPTCCNC | |
| SCHEMBL11961745 | 0.80 | CHEK1 (0.49) | CHEK1CHEK2CCNCCDK8CDK19 | |
| Hydrochloric Acid SCHEMBL3738348 | 0.79 | CHEK1 (0.48) | CHEK1CHEK2CCNCCDK8CDK19 | |
| Hydrochloric Acid SCHEMBL3738333 | 0.79 | CHEK1 (0.48) | CHEK1CHEK2CCNCCDK8CDK19 | |
| SCHEMBL3721746 | 0.77 | KIT (0.43) | CHEK1CHEK2CDK8CDK2JAK3 | |
| SCHEMBL3730739 | 0.77 | AKT3 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242757-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |