Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 7/20 | 0.50 |
| ▸ | HTR7 | P34969 | 7/20 | 0.50 |
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | HTR2B | P41595 | 5/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3716314 | 0.99 | CHEK1 (0.57) | CHEK1CHEK2HTR6HTR7HTR1A | |
| Hydrochloric Acid SCHEMBL3714080 | 0.99 | CHEK1 (0.57) | CHEK1CHEK2HTR6HTR7HTR1A | |
| Hydrochloric Acid SCHEMBL3714976 | 0.86 | HTR1A (0.56) | CHEK1CHEK2HTR6HTR7HTR1A | |
| SCHEMBL3662967 | 0.84 | CHEK1 (0.55) | CHEK1CHEK2LMNAMAPTCCNC | |
| Hydrochloric Acid SCHEMBL3718468 | 0.81 | HTR2C (0.49) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL3730730 | 0.79 | CHEK1 (0.38) | CHEK1CHEK2HTR6HTR7HTR1A | |
| Hydrochloric Acid SCHEMBL3716594 | 0.78 | CHEK1 (0.38) | CHEK1CHEK2HTR6HTR7HTR1A | |
| SCHEMBL3717407 | 0.77 | CKS1B (0.53) | CHEK1CHEK2 | |
| SCHEMBL4164895 | 0.76 | CHEK1 (0.54) | CHEK1CHEK2HTR6HTR7HTR1A | |
| SCHEMBL3736680 | 0.76 | AKT2 (0.41) | CHEK1CHEK2HTR6HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |