Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675719 | 0.89 | JAK2 (0.57) | JAK2CHEK1ACHEHRH3TLR8 | |
| SCHEMBL676204 | 0.82 | CHEK1 (0.67) | JAK2CHEK1ACHEHRH3CSF1R | |
| SCHEMBL3727833 | 0.82 | JAK2 (0.50) | JAK2CHEK1ACHEHRH3TLR8 | |
| SCHEMBL678879 | 0.81 | JAK2 (0.49) | JAK2CHEK1ACHEHRH3TLR8 | |
| SCHEMBL675875 | 0.81 | JAK2 (0.52) | JAK2CHEK1ACHEHRH3TLR8 | |
| SCHEMBL3667665 | 0.79 | ALK (0.61) | JAK2CHEK1ACHEHRH3TLR8 | |
| SCHEMBL676493 | 0.79 | JAK2 (0.49) | JAK2CHEK1ACHEHRH3TLR8 | |
| SCHEMBL675874 | 0.79 | JAK2 (0.49) | JAK2CHEK1ACHEHRH3TLR8 | |
| SCHEMBL675877 | 0.79 | JAK2 (0.49) | JAK2CHEK1ACHEHRH3TLR8 | |
| SCHEMBL675460 | 0.79 | JAK2 (0.49) | JAK2CHEK1ACHEHRH3TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |