Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676828 | 0.89 | ALK (0.59) | ALKJAK2CHEK1ACHEHRH3 | |
| SCHEMBL3723321 | 0.82 | ALK (0.50) | ALKJAK2CHEK1ACHEHRH3 | |
| SCHEMBL675458 | 0.81 | JAK2 (0.51) | ALKJAK2CHEK1ACHEHRH3 | |
| SCHEMBL676204 | 0.81 | CHEK1 (0.67) | JAK2CHEK1ACHEHRH3CSF1R | |
| SCHEMBL675457 | 0.79 | JAK2 (0.48) | ALKJAK2CHEK1ACHEHRH3 | |
| SCHEMBL3662982 | 0.79 | JAK2 (0.57) | ALKJAK2CHEK1ACHEHRH3 | |
| SCHEMBL676734 | 0.79 | ALK (0.49) | ALKJAK2CHEK1ACHETLR8 | |
| SCHEMBL676735 | 0.79 | ALK (0.49) | ALKJAK2CHEK1ACHETLR8 | |
| SCHEMBL31240772 | 0.79 | CSF1R (0.67) | JAK2HRH3MAPKAPK2CSF1RCDK1 | |
| SCHEMBL675719 | 0.77 | JAK2 (0.57) | JAK2CHEK1ACHEHRH3MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |