Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | CCNC | P24863 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | CCNH | P51946 | 1/20 | 0.56 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 3/20 | 0.54 |
| ▸ | FYN | P06241 | 6/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29476743 | 0.84 | MKNK1 (0.68) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL12269997 | 0.83 | CCNT1 (0.55) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL3636687 | 0.81 | CCNT1 (0.53) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL31422694 | 0.80 | PARP1 (0.64) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL2431097 | 0.80 | PARP1 (0.64) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL1346081 | 0.80 | ERN1 (0.57) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL29724745 | 0.80 | CCNT1 (0.58) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL14936808 | 0.80 | CCNT1 (0.58) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL3662920 | 0.79 | MKNK1 (0.71) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL3664142 | 0.79 | FYN (0.57) | CCNT1CCND1CCNCCDK8CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642788-B2 | Activators of executioner procaspases 3, 6 and 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-04 | — | — | US | disclosed |
| CN-101965189-A | Activators of pro-caspase 3, 6 and 7 | UNIV CALIFORNIA | 2011-02-02 | — | — | CN | disclosed |
| EP-2237784-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | The Regents of the University of California (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009089508-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | WO | disclosed |