Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 5/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 7/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | ATF4 | P18848 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665544 | 0.96 | SCN9A (0.39) | PRKAA2SLC6A5SLC6A4SCN9AADRB2 | |
| SCHEMBL3666576 | 0.95 | PRKAA2 (0.43) | PRKAA2SLC6A5SLC6A4TEAD1SCN9A | |
| SCHEMBL648611 | 0.92 | PRKAA2 (0.43) | PRKAA2SLC6A5SLC6A4TEAD1SCN9A | |
| SCHEMBL647134 | 0.88 | SLC6A4 (0.41) | PRKAA2SLC6A4TEAD1SCN9AADRB2 | |
| SCHEMBL647133 | 0.88 | SLC6A4 (0.41) | PRKAA2SLC6A4TEAD1SCN9AADRB2 | |
| SCHEMBL648854 | 0.87 | PRKAA2 (0.44) | PRKAA2SLC6A5SLC6A4TEAD1ADRB2 | |
| SCHEMBL3659838 | 0.84 | SLC6A4 (0.43) | PRKAA2SLC6A4TEAD1SCN9AATF4 | |
| SCHEMBL649203 | 0.83 | HDAC4 (0.45) | SLC6A4 | |
| SCHEMBL4403528 | 0.83 | PRKAA2 (0.44) | PRKAA2EPHX2 | |
| SCHEMBL647012 | 0.83 | PRKAA2 (0.44) | PRKAA2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |