Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663244 | 0.96 | PRKAA2 (0.43) | SCN9APRKAA2SLC6A4SLC6A5ADRB2 | |
| SCHEMBL647133 | 0.92 | SLC6A4 (0.41) | SCN9APRKAA2SLC6A4ADRB2 | |
| SCHEMBL647134 | 0.92 | SLC6A4 (0.41) | SCN9APRKAA2SLC6A4ADRB2 | |
| SCHEMBL3666576 | 0.91 | PRKAA2 (0.43) | SCN9APRKAA2SLC6A4SLC6A5ADRB2 | |
| SCHEMBL648611 | 0.88 | PRKAA2 (0.43) | SCN9APRKAA2SLC6A4SLC6A5ADRB2 | |
| SCHEMBL3659838 | 0.87 | SLC6A4 (0.43) | SCN9APRKAA2SLC6A4UTS2R | |
| SCHEMBL649433 | 0.84 | HDAC4 (0.46) | SCN9ASLC6A4 | |
| SCHEMBL649869 | 0.84 | HDAC4 (0.46) | SCN9ASLC6A4 | |
| SCHEMBL4405724 | 0.84 | PRKAA2 (0.40) | PRKAA2MEN1KMT2AUTS2R | |
| SCHEMBL648854 | 0.83 | PRKAA2 (0.44) | PRKAA2SLC6A4SLC6A5ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |