Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521287 | 0.80 | ABL1 (0.45) | ABL1RAB9ANPC1SMN1; SMN2TLR9 | |
| SCHEMBL3519887 | 0.74 | EGLN3 (0.66) | ABL1EGLN3ALDH1A1 | |
| SCHEMBL3518478 | 0.73 | EGLN3 (0.50) | ABL1RAB9ANPC1MAPTKMT2A | |
| SCHEMBL3435784 | 0.72 | ERN1 (0.44) | MAPTSMN1; SMN2NFKB1PARP1HPGD | |
| SCHEMBL27825159 | 0.70 | KMT2A (0.46) | RAB9ANPC1KMT2APARP1IKBKB | |
| SCHEMBL3527577 | 0.70 | TLR9 (0.43) | RAB9ANPC1MAPTSMN1; SMN2TLR9 | |
| SCHEMBL27825157 | 0.69 | PARP1 (0.45) | MAPTPARP1IKBKBMAPK1HPGD | |
| SCHEMBL3521893 | 0.69 | SMN1; SMN2 (0.52) | ABL1RAB9ANPC1MAPTKMT2A | |
| SCHEMBL3518993 | 0.67 | EGLN3 (0.60) | ABL1EGLN3MAPK1 | |
| SCHEMBL3761711 | 0.67 | EGLN3 (0.56) | ABL1MAPTEGLN3MAPK1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |