Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25235346 | 0.78 | CA12 (0.57) | ERN1EGLN1MMP2TSHRMETAP2 | |
| SCHEMBL31022701 | 0.78 | CA12 (0.57) | ERN1EGLN1MMP2TSHRMETAP2 | |
| SCHEMBL9191925 | 0.75 | ALDH1A1 (0.47) | ERN1EGLN1MMP2TSHRMETAP2 | |
| SCHEMBL16040593 | 0.75 | ALDH1A1 (0.60) | ERN1EGLN1MMP2TSHRMETAP2 | |
| SCHEMBL31057838 | 0.75 | ALDH1A1 (0.60) | ERN1EGLN1MMP2TSHRMETAP2 | |
| SCHEMBL31022679 | 0.73 | ERN1 (0.54) | ERN1EGLN1MMP2TSHRMETAP2 | |
| SCHEMBL3663307 | 0.72 | ABL1 (0.43) | ALDH1A1PARP1MAPTNFKB1SMN1; SMN2 | |
| SCHEMBL6983292 | 0.70 | LMNA (0.63) | METAP2METAP1ALDH1A1KDM4EPARP1 | |
| SCHEMBL3394717 | 0.69 | EGLN1 (0.69) | ERN1EGLN1ALDH1A1MAPTSLC40A1 | |
| SCHEMBL6078786 | 0.67 | CES2 (0.50) | ALDH1A1KDM4ELMNAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2224926-A1 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009070644-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |