Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1678505 | 0.79 | HTT (0.45) | HTTKDM4ETDP1LOXL2ALDH1A1 | |
| SCHEMBL3576313 | 0.79 | HTT (0.45) | HTTKDM4ETDP1LOXL2ALDH1A1 | |
| SCHEMBL10716701 | 0.77 | LOXL2 (0.42) | HTTCYP19A1LOXL2ALDH1A1CYP1A2 | |
| SCHEMBL14667472 | 0.77 | CTBP2 (0.52) | KDM4EALDH1A1CYP2D6CYP2C19TSHR | |
| SCHEMBL10177334 | 0.77 | CTBP2 (0.52) | KDM4EALDH1A1CYP2D6CYP2C19TSHR | |
| SCHEMBL3658960 | 0.77 | CTBP2 (0.52) | KDM4EALDH1A1CYP2D6CYP2C19TSHR | |
| SCHEMBL4681053 | 0.77 | LOXL2 (0.46) | HTTCYP19A1LOXL2ALDH1A1CYP1A2 | |
| SCHEMBL10744042 | 0.76 | NAPRT (0.55) | KDM4ETDP1CYP19A1ALDH1A1CYP1A2 | |
| SCHEMBL10744051 | 0.76 | NAPRT (0.55) | KDM4ETDP1CYP19A1ALDH1A1CYP1A2 | |
| SCHEMBL362289 | 0.76 | CTBP2 (0.55) | TDP1ALDH1A1CYP1A2GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |