Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2266470 | 0.98 | PDE10A (0.55) | PDE10AF10KMT2AKDM4EGAA | |
| SCHEMBL3639406 | 0.91 | PDE10A (0.59) | PDE10AF10KMT2AKDM4EGAA | |
| SCHEMBL2844229 | 0.82 | PDE10A (0.52) | PDE10AF10KMT2AKDM4EGAA | |
| SCHEMBL9194512 | 0.78 | CYP1A2 (0.61) | PDE10AF10KMT2A | |
| SCHEMBL9194507 | 0.78 | CYP1A2 (0.48) | KMT2AALDH1A1POLB | |
| SCHEMBL9123593 | 0.78 | KMT2A (0.62) | PDE10AF10KMT2AKDM4EPARP1 | |
| SCHEMBL7559296 | 0.76 | GAA (0.70) | PDE10AF10KMT2AGAAPARP1 | |
| SCHEMBL2266891 | 0.76 | KMT2A (0.49) | KMT2AKDM4EGAAPARP1MAPT | |
| SCHEMBL7332580 | 0.75 | F10 (0.53) | PDE10AF10KMT2AKDM4EGAA | |
| SCHEMBL9126024 | 0.75 | KDM4E (0.58) | KMT2AKDM4EPARP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152670-A1 | BRIDGED SIX-MEMBERED RING COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008132679-A1 | BRIDGED SIX-MEMBERED RING COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-06 | — | — | WO | disclosed |