Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 8/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662882 | 0.72 | PARP1 (0.40) | PARP1 | |
| SCHEMBL5808501 | 0.69 | HTR2C (0.44) | PARP1HTR2CIKBKBCHUKPLAT | |
| SCHEMBL30554038 | 0.69 | PARP1 (0.56) | PARP1HTR2CKCNH2IKBKBCHUK | |
| SCHEMBL21714170 | 0.69 | LIMK1 (0.51) | PARP1HTR2CHTR2AKCNH2IKBKB | |
| SCHEMBL17042189 | 0.68 | MEN1 (0.39) | — | |
| SCHEMBL29372456 | 0.68 | MEN1 (0.39) | — | |
| SCHEMBL3809365 | 0.66 | PARP1 (0.51) | PARP1HTR2CIKBKBCHUK | |
| SCHEMBL28325510 | 0.66 | PARP1 (0.57) | PARP1IKBKBCHUK | |
| SCHEMBL4077380 | 0.65 | HTR2C (0.51) | PARP1HTR2CHTR2AKCNH2TLR9 | |
| Acetamide SCHEMBL27654523 | 0.65 | HTR2C (0.58) | PARP1HTR2CIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257297-A1 | METHODS OF MODULATING THE ACTIVITY OF THE MC5 RECEPTOR AND TREATMENT OF CONDITIONS RELATED TO THIS RECEPTOR | Mimetica Pty Limited (AU) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009105824-A1 | METHODS OF MODULATING THE ACTIVITY OF THE MC5 RECEPTOR AND TREATMENT OF CONDITIONS RELATED TO THIS RECEPTOR | MIMETICA PTY LTD (AU) | 2009-09-03 | — | — | WO | disclosed |