Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | PARP1 | P09874 | 11/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3809365 | 0.82 | PARP1 (0.51) | HTR2CPARP1CDC7IKBKBCHUK | |
| SCHEMBL28470220 | 0.82 | MAPK1 (0.39) | PARP1 | |
| SCHEMBL28325510 | 0.79 | PARP1 (0.57) | PARP1CDC7IKBKBCHUKPARP2 | |
| SCHEMBL28478841 | 0.77 | F2 (0.38) | PLAT | |
| SCHEMBL2790537 | 0.76 | ADRB1 (0.42) | MEN1KMT2A | |
| SCHEMBL30760594 | 0.76 | QDPR (0.49) | HTR2CPARP1CDC7IKBKBCHUK | |
| SCHEMBL25436217 | 0.76 | SIRT3 (0.37) | PARP1MEN1CYP2D6KMT2A | |
| SCHEMBL28571503 | 0.75 | MKNK1 (0.46) | PARP1PARP2 | |
| SCHEMBL28175941 | 0.74 | MEN1 (0.43) | PARP1CDC7MEN1KMT2A | |
| SCHEMBL27544733 | 0.74 | HTR2C (0.40) | HTR2CPLATMEN1CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615643-A1 | 4-PHENYL-PIPERIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF OPIOID RECEPTORS | Pfizer Products Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089370-A1 | 4-PHENYL-PIPERIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF OPIOID RECEPTORS | PFIZER PRODUCTS INC. (US) | 2004-10-21 | — | — | WO | disclosed |