SCHEMBL3663634

SCHEMBL3663634

COc1ccc(COc2cc(OCc3ccc(OC)cc3)c(C(C)C)cc2C2=NNCCN2c2ccc3c(ccn3C)c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 14/20 0.38
HSP90AB1 P08238 14/20 0.38
HSP90B1 P14625 1/20 0.37
TRAP1 Q12931 1/20 0.37
CHRNA7 P36544 1/20 0.34
TLR7 Q9NYK1 2/20 0.32
TLR9 Q9NR96 1/20 0.32
CACNA1H O95180 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL184460 0.86 HSP90AA1 (0.40) HSP90AA1HSP90AB1HSP90B1TRAP1CHRNA7
SCHEMBL1852028 0.72 HSP90AA1 (0.49) HSP90AA1HSP90AB1HSP90B1TRAP1
SCHEMBL14123937 0.69 HSP90AB1 (0.64) HSP90AA1HSP90AB1HSP90B1TRAP1
SCHEMBL1304291 0.68 HSP90AA1 (0.54) HSP90AA1HSP90AB1
SCHEMBL31296853 0.67 HSP90AA1 (0.56) HSP90AA1HSP90AB1HSP90B1TRAP1
SCHEMBL1148585 0.67 HSP90AA1 (0.58) HSP90AA1HSP90AB1
SCHEMBL2268041 0.65 HSP90AB1 (0.57) HSP90AA1HSP90AB1HSP90B1TRAP1
SCHEMBL3665914 0.65 KEAP1 (0.38) HSP90AA1HSP90AB1CHRNA7CACNA1H
SCHEMBL1305171 0.65 HSP90AA1 (0.69) HSP90AA1HSP90AB1
SCHEMBL184281 0.64 CHRNA7 (0.36) HSP90AA1HSP90AB1CHRNA7CACNA1H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2155694-A2 TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS Synta Pharmaceuticals Corporation (US) 2010-02-24 EP disclosed
WO-2008118391-A2 TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS SYNTA PHARMACEUTICALS CORP. (US) 2008-10-02 WO disclosed