Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | IDE | P14735 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192015 | 0.82 | KIT (0.48) | MAPTLMNAALDH1A1GPR119OPRD1 | |
| SCHEMBL192014 | 0.82 | KIT (0.48) | MAPTLMNAALDH1A1GPR119OPRD1 | |
| SCHEMBL926142 | 0.80 | AKT1 (0.39) | KMT2AMEN1ALDH1A1KDM4EAKT3 | |
| SCHEMBL3663311 | 0.80 | AKT1 (0.54) | AKT3AKT1AKT2 | |
| SCHEMBL3123863 | 0.78 | AKT1 (0.52) | MAPTSMN1; SMN2TSHRRXFP1KMT2A | |
| SCHEMBL3128363 | 0.77 | AKT1 (0.41) | MAPTSMN1; SMN2TSHRRXFP1KMT2A | |
| SCHEMBL30297596 | 0.76 | MAPT (0.52) | MAPTSMN1; SMN2TSHRRXFP1KMT2A | |
| SCHEMBL12194049 | 0.75 | HRH4 (0.41) | SMN1; SMN2TSHRKMT2ALMNAMEN1 | |
| SCHEMBL30297571 | 0.74 | MAPT (0.50) | MAPTSMN1; SMN2TSHRRXFP1KMT2A | |
| SCHEMBL16488552 | 0.73 | JAK2 (0.39) | MAPTSMN1; SMN2TSHRRXFP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240455-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR | Array Biopharma, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089453-A9 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR | ARRAY BIOPHARMA INC. (US) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009089453-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |
| EP-2049500-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008006032-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |