Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12004836 | 0.89 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL17455125 | 0.88 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL16113625 | 0.84 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL17455316 | 0.84 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8102784 | 0.82 | TSHR (0.58) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL17455348 | 0.81 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL17455382 | 0.80 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL16114671 | 0.80 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL16114753 | 0.80 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL16115182 | 0.79 | SLC6A3 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944618-B2 | Inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2018-04-17 | — | — | US | disclosed |
| US-20160024044-A1 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2016-01-28 | — | — | US | disclosed |
| WO-2014159251-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2014-10-02 | — | — | WO | disclosed |
| US-8507500-B2 | Inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-08-13 | — | — | US | disclosed |
| US-8440724-B2 | Inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| US-20130059864-A1 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-03-07 | — | — | US | disclosed |
| US-20120220665-A1 | Inhibiting Neurotransmitter Reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2012-08-30 | — | — | US | disclosed |
| US-20100280127-A1 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2010-11-04 | — | — | US | disclosed |
| EP-2234960-A2 | INHIBITING NEUROTRANSMITTER REUPTAKE | Mayo Foundation for Medical Education and Research (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20100168246-A1 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | RICHELSON ELLIOTT | 2010-07-01 | — | — | US | disclosed |
| US-7214826-B2 | Amine compounds and inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2007-05-08 | — | — | US | disclosed |
| EP-1414425-A4 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION (US) | 2007-04-11 | — | — | EP | disclosed |
| US-20050215647-A1 | Amine compounds and inhibiting neurotransmitter reuptake | Mayo Foundation for Medical Education and Research and Virginia Tech Intellectual Properties, Inc. | 2005-09-29 | — | — | US | disclosed |
| US-6914080-B2 | Amine compounds and inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2005-07-05 | — | — | US | disclosed |
| US-20040143022-A1 | Amine compounds and inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2004-07-22 | — | — | US | disclosed |
| EP-1414425-A1 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2004-05-06 | — | — | EP | disclosed |
| US-6700018-B2 | 3-HYDROXY-2-(2-NAPHTHYL)PENTYLAMINE DERIVATIVES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2004-03-02 | — | — | US | disclosed |
| US-20030027869-A1 | Amine compounds and inhibiting neurotransmitter reuptake | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2003-02-06 | — | — | US | disclosed |
| WO-2003007929-A1 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2003-01-30 | — | — | WO | disclosed |
| US-6069177-A | ADMINISTERING TO THE HUMAN AN EFFECTIVE ANTIDEPRESSANT DOSE OF THE COMPOUND 3-HYDROXY-4,4-DIMETHYL-2-(2'-NAPHTHYL)PENTYL-N,N-DIMETHYLAMINE OR SALT | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (HK) | 2000-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024044-A1 | INHIBITING NEUROTRANSMITTER REUPTAKE | SLC6A2, SLC18A2, SLC6A4 | SLC6A2 1/4885SLC6A4 3/4885SLC6A3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.