Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 18/20 | 1.00 |
| ▸ | CSNK1D | P48730 | 18/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 15/20 | 1.00 |
| ▸ | CSNK1A1 | P48729 | 15/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 14/20 | 1.00 |
| ▸ | MINK1 | Q8N4C8 | 13/20 | 1.00 |
| ▸ | MAPK8 | P45983 | 12/20 | 1.00 |
| ▸ | CSNK1G2 | P78368 | 10/20 | 1.00 |
| ▸ | CSNK1G3 | Q9Y6M4 | 9/20 | 1.00 |
| ▸ | GSK3B | P49841 | 9/20 | 1.00 |
| ▸ | PRKD2 | Q9BZL6 | 12/20 | 0.75 |
| ▸ | MAP4K5 | Q9Y4K4 | 9/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.75 |
| ▸ | TAOK1 | Q7L7X3 | 11/20 | 0.69 |
| ▸ | LIMK1 | P53667 | 7/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.69 |
| ▸ | FRK | P42685 | 3/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724163 | 0.90 | MAPK9 (1.00) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL13342092 | 0.86 | MAPK9 (1.00) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL3663945 | 0.81 | MAPK9 (0.68) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL3523789 | 0.81 | MAPK9 (1.00) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL3524337 | 0.80 | MAPK9 (0.66) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL3523159 | 0.78 | MAPK9 (1.00) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL3663948 | 0.78 | MAPK9 (1.00) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL27741884 | 0.78 | MAPK9 (0.78) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL14600660 | 0.73 | MAPK9 (1.00) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 | |
| SCHEMBL13342091 | 0.72 | MAPK9 (0.83) | MAPK9CSNK1DMAP4K4CSNK1A1PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139329-A1 | NOVEL IMIDAZO BASED HETEROCYCLES | Abbott Laboratories (US) | 2010-01-06 | — | — | EP | disclosed |
| US-20080249305-A1 | Novel imidazole based heterocycles | ABBOTT LABORATORIES | 2008-10-09 | — | — | US | disclosed |
| US-20080249305-A1 | Novel imidazole based heterocycles | ABBOTT LABORATORIES | 2008-10-09 | — | — | US | disclosed |
| US-20080249305-A1 | Novel imidazole based heterocycles | ABBOTT LABORATORIES | 2008-10-09 | — | — | US | disclosed |
| US-20080242862-A1 | Novel imidazo based heterocycles | ABBOTT LABORATORIES | 2008-10-02 | — | — | US | disclosed |
| US-20080242862-A1 | Novel imidazo based heterocycles | ABBOTT LABORATORIES | 2008-10-02 | — | — | US | disclosed |
| US-20080242862-A1 | Novel imidazo based heterocycles | ABBOTT LABORATORIES | 2008-10-02 | — | — | US | disclosed |
| WO-2008118485-A1 | NOVEL IMIDAZO BASED HETEROCYCLES | ABBOTT LABORATORIES (US) | 2008-10-02 | — | — | WO | disclosed |
| WO-2008118485-A1 | NOVEL IMIDAZO BASED HETEROCYCLES | ABBOTT LABORATORIES (US) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242862-A1 | Novel imidazo based heterocycles | CDK4, CDK2, MAP3K15 | MAPK9 274/4885CSNK1D 669/4885MAP4K4 22/4885 |
| US-20080249305-A1 | Novel imidazole based heterocycles | MAP3K5, MAP3K15, MAP3K20 | MAPK9 249/4885CSNK1D 743/4885MAP4K4 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.