Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11178916 | 0.71 | CHRM1 (0.64) | GAASMN1; SMN2ALOX12ALDH1A1TDP1 | |
| SCHEMBL1684895 | 0.70 | — | — | |
| SCHEMBL10985089 | 0.70 | ALDH1A1 (0.72) | GAASMN1; SMN2ALDH1A1TDP1POLB | |
| SCHEMBL1111736 | 0.69 | GAA (0.67) | GAASMN1; SMN2ALDH1A1TDP1TP53 | |
| SCHEMBL6891992 | 0.68 | MAPT (0.41) | GAASMN1; SMN2ALDH1A1TDP1POLB | |
| SCHEMBL4762356 | 0.68 | GAA (0.61) | GAASMN1; SMN2ALDH1A1TDP1TP53 | |
| SCHEMBL1219954 | 0.67 | GAA (0.65) | GAASMN1; SMN2ALDH1A1TDP1TP53 | |
| SCHEMBL1267094 | 0.67 | GAA (0.65) | GAASMN1; SMN2ALDH1A1TDP1TP53 | |
| SCHEMBL29588936 | 0.67 | GAA (0.65) | GAASMN1; SMN2ALDH1A1TDP1TP53 | |
| SCHEMBL3629079 | 0.67 | GAA (0.70) | GAASMN1; SMN2ALDH1A1TDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238140-A2 | SUBSTITUTED HETEROARYLAMIDE DIAZEPINOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | claimed |
| WO-2009095792-A2 | SUBSTITUTED HETEROARYLAMIDE DIAZEPINOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2009-08-06 | — | — | WO | claimed |